Cisplatin in animal bedding
WebOct 7, 2024 · Cisplatin causes acute and chronic effects in the gastrointestinal tract. A single injection of cisplatin causes pica, a rodent-specific behavior of nausea, which reflects as a progressive reduction in food intake, increase in non-nutritive material intake (for instance bedding) and decreased gastric motility . WebApr 17, 2024 · Animals. Animal preparation All protocols were approved by the Institutional Animal Care and Use Committee and conducted accordingly to the Guide for the Care and Use of Laboratory Animals …
Cisplatin in animal bedding
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WebMar 2, 2005 · Animals receiving cisplatin were prehydrated for 1 hour with 200 mL of sodium chloride with 150 mg/kg sodium thiosulfate (250 mg/mL, American Reagent Laboratory, Shirley, NY). Over 3 hours following the cisplatin infusion, they received 300 mL NaCl mixed with 350 mg/kg sodium thiosulfate. Web2. Animal cages and bedding are considered hazardous for a minimum of 3 days (36 hours) after an injection. The first cage change after each drug administration is to be done no sooner than 3 days after the administration. 3. The bedding is considered contaminated and requires special handling. The first bedding change
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Webcisplatin doses of 18 and 22 mg/kg, the half-life of cefepime was signiÞcantly prolonged of 18 mg/kg cisplatin. Serum levels of cefepime after the pretreatment with … WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms …
WebApr 8, 2024 · First, we did not include additional animal groups, e.g., normal mice, MNU and INS-GAS mice that should be treated with PEITC or cisplatin alone and combination of PEITC plus cisplatin to explore the possibilities that PEITC may have differential effects on gastric cancer cells compared to normal gastric epithelial cells and that there is ...
WebJul 12, 2024 · Cisplatin is used to treat a number of different tumors in dogs. The most common ones include osteosarcoma, squamous cell carcinoma, bladder tumors, ovarian … chip\u0027s 9aWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various … chip\u0027s 93WebFeb 21, 2003 · In short, cisplatin was administered twice a week at a dose of 2 mg kg −1 by intraperitoneal injection. Routinely, rats thus treated develop a sensory neuropathy after 2–3 weeks, as evidenced by slowing of the sensory nerve conduction velocity. graphic card 2060 tiWebFeb 1, 2024 · If cisplatin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you … chip\u0027s 9cWebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … chip\u0027s 9eWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). Unfortunately, there are no therapeutic ... chip\u0027s 98WebMar 15, 2024 · Cisplatin, a heavy metal complex, is one of the most effective chemotherapeutic agents used for the treatment of a wide variety of malignancies (Zhang and Lippard, 2003). However, dose-dependent and cumulative nephrotoxicity is a major side effect of cisplatin, leading to reduction in dosage or ceasing its use. chip\u0027s 9b