WebNov 15, 2024 · Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. WebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. Capparaceae Medicine & Life Sciences 100%. Proximal Kidney Tubule Medicine & Life Sciences 50%. Cisplatin Medicine ...
A Systematic Review of Strategies to Prevent Cisplatin‐Induced ...
WebFeb 5, 2014 · Nephrotoxicity caused by cisplatin is a well-known side effect and is dose-limiting toxicity that most commonly manifests as an acute and chronic impairment of renal function in almost all cisplatin-containing regimens. Nephrotoxicity appears to be clinical problem in 28–42% of patients treated with cisplatin in clinical practice ( 1–3 ). WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk... ct invasion\u0027s
[Magnesium premedication prevents Cisplatin-induced nephrotoxicity …
WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebFeb 15, 2024 · We then examined GSDME cleavage in a cisplatin-induced mouse model of nephrotoxicity and found that cisplatin increased serum creatinine and BUN (Fig. 1 E, F). HE staining exhibited severe... WebFeb 2, 2024 · Celastrol, a potent chemotherapeutic agent, could ameliorate cisplatin-induced nephrotoxicity through suppressing NF-κB and protecting mitochondrial function in vitro and in vivo (Yu et al., 2024). Similarly, polysulfide and H2S could afford protection against cisplatin-caused nephrotoxicity via persulfidating STAT3 and IκKβ and … earth month 2023