Webcreted cryptdins function as intrinsic components of the intes-tinal inflammatory response. Pore formation in eukaryotic cells by a variety of agents causes many biological effects including cytokine release (11, 12). The complement membrane attack complex (C5–9), for example, forms pores on endothelial cells that induce IL-8 Webplural of cryptdin ... Definition from Wiktionary, the free dictionary

Mouse intestinal cryptdins exhibit circadian oscillation

WebMar 21, 2014 · Mouse enteric alpha-defensins called cryptdins are expressed in the granules of Paneth cells and are secreted into the lumen of intestinal crypts in response to bacterial stimuli . Cryptdins are broad-spectrum AMPs due to their ability to kill various bacteria [ 8 – 10 ], parasites [ 11 ] and enveloped viruses [ 12 ] in vitro. WebMurine cryptdins reach concentrations of 15–100 mg/ml in the crypt microenvironment. 29 These concentrations are at least 1000 times higher than minimal bactericidal concentrations in vitro, indicating the potential … sims 4 style wheel

National Center for Biotechnology Information

WebMay 7, 2004 · Cryptdins act by forming anion-conductive channels in microbial cell membranes that depolarize and kill the microbe (6, 7, 8, 9). We also find that certain … WebCryptdins kill microbes by forming pores in their limiting membranes. The cryptdin isoforms 2 and 3 also can form anion-conductive pores in eukaryotic cell membranes, thus … WebAug 5, 1997 · Because cryptdins are homologs of molecules known to form anion conductive pores in phospholipid bilayers, we tested whether these endogenous … rcht terlipressin