Foxm1 macrophage
WebFoxm1 contributes to the bone destruction caused by AtoMs We performed RNA sequencing (RNA-Seq) transcriptomic analysis of R1, R2′, and R3′ (AtoMs) cells, and predicted upstream regulators through bioinformatics analysis performed using Ingenuity Pathway Analysis. WebLoss of FOXM1 in macrophages promotes pulmonary. fibrosis by activating p38 MAPK signaling pathway. Idiopathic pulmonary fibrosis (IPF) is a chronic disease with high …
Foxm1 macrophage
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WebDec 2, 2024 · As FoxM1 is a critical regulator of oxidative responses , the upregulation of FoxM1 expression reduces ROS by stimulating the expression of ROS scavenger genes such as Sod 1 and Nrf 2 [16,44,45]. During osteoclast differentiation, the expression of FoxM1 was significantly reduced, suggesting the significant involvement of ROS in this process. WebJan 1, 2024 · CD163 and FOXM1 expression levels were induced even in recurrent grade I meningioma, suggesting that macrophage polarization and pro-mitotic transcriptional factor might be associated with...
WebDec 10, 2013 · The same research team has further shown that expression of FOXM1 in macrophages is required for pulmonary inflammation, recruitment of macrophages into the tumor site and lung tumor growth [146, 147]. Collectively, those findings strongly support the potential role of FOXM1 in TAMs infiltration and recruitment and tumor development and ... WebSep 12, 2024 · FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for …
WebFOXM1 is a transcription factor and is not expressed in quiescent lungs. Herein, we show that FOXM1 is highly expressed in pulmonary macrophages within fibrotic lungs of IPF patients and mouse fibrotic lungs. Macrophage-specific deletion of Foxm1 in mice (myFoxm1-/-) exacerbated pulmonary fibrosis.
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WebForkhead box M1 (FOXM1), a member of the Forkhead Box (Fox) family, is recognized as a critical proliferationrelated transcription factor in cell cycle progression, DNA damage repair, and other... sprache tastatur ändern windows 10WebFOXM1 regulates angiogenesis via expression of vascular endothelial growth factor, invasion via matrix metalloproteinase, survival, cell cycle, tumor cell migration, and DNA … sprache talinWebAug 23, 2012 · Foxm1 regulates expression of genes critical for pulmonary inflammation and macrophage migration To identify potential target genes regulated by Foxm1 in … sprache shortcutWebNov 18, 2024 · Macrophages comprise a variety of subsets with diverse biological activities, contributing to tissue homeostasis and a broad spectrum of pathogenesis 1, 2, 3, 4. In … sprache soraniWebMay 7, 2024 · In this regard, FOXM1 has been implicated in both recruitment and functional modulation of macrophages in a butylated hydroxytoluene-induced model of lung inflammation . Since M2 macrophages promote tissue fibrosis in part via elaboration of TGF-β ( 67 ), it is possible that the inhibitory effects of Sio A on lung TGF-β levels may also … sprachethikWebDec 1, 2024 · Some activated macrophages, stimulated by M-CSF, differentiate into precursors with FoxM1 and are designated arthritis-associated osteoclastogenic macrophages (AtoM) [78]. Boxes indicate cytokines ... shenzhen along investmentWebDec 13, 2024 · Macrophages mediate vagus-induced hepatic FoxM1 activation. a (Upper panels) Representative images of liver sections immunostained for F4/80 from mice 24 h after receiving control and... sprache startbildschirm windows 10