Webhuman DUB cDNA library of 65 genes and an siRNA li-brary of 98 genes, and identified USP20 as a deubiquiti-nase (DUB) that regulates SNAI2 ubiquitination and stability. … WebClassifications. A — HUMAN NECESSITIES; A61 — MEDICAL OR VETERINARY SCIENCE; HYGIENE; A61K — PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES; A61K47/00 — Medicinal p
Deubiquitinase USP20 promotes breast cancer …
WebTransfection efficiency was not determined in this experiment... Verification of pCR4Blunt-‐TOPO plasmids containing esiRNA Web11 Apr 2024 · To identify novel ubiquitin-related factors with a potential role in mitosis, we previously performed a high-content visual siRNA screen in HeLa cells for human ubiquitin-binding domain (UBD) proteins (Krupina et al, 2016) and assessed the phenotypes of irregular nuclear shape that are often the result of chromosome segregation defects … irstha
The deubiquitinase USP7 promotes HNSCC progression …
WebUbiquitination has crucial roles in many cellular processes and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets. As individual E2 enzymes have many different substrates and interactions … WebThe gel was stained with ethidium bromide, and siRNA bands were detected at 302 nm using Azure C300 (Dublin, CA, USA) as previously described. 55 The USP14 siRNA … WebIt is not difficult to imagine that deregulation of the Hh pathway could contribute to tumorigenesis or accelerate the rate of tumor growth. 10 Anomalous activation of the SHh pathway has been shown in many human cancers, including basal cell carcinoma (BCC), 11 malignant gliomas, 12 medulloblastoma, 13 leukemias, 14 and carcinomas of the breast, … portal method frame