Lhx2 hepatic stellate cell
WebArticle Snippet: Human hepatic stellate cell line LX-2 and HEK293T Phoenix-ampho retrovirus packaging cells (ATCC) were cultured in DMEM supplemented with 10% FBS … WebThe aim of the study was the pioneering retrospective ultrastructural evaluation of respective forms of hepatic stellate cells (HSCs) and analysis of their crosstalk with other adjacent nonparenchymal cells (NPCs), especially Kupffer cells/macrophages (KCs/MPs), in pediatric autoimmune hepatitis (AIH). Methods: Ultrastructural assessment of the ...
Lhx2 hepatic stellate cell
Did you know?
Web18. okt 2024. · 2024年10月5日，美国哥伦比亚大学Robert F. Schwabe研究组发文题为Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis，通过对 … WebBACKGROUND AND AIM: : Activation of hepatic stellate cells (HSC) results in the transdifferentiation of the resting (quiescent) phenotype to one characterized by loss of vitamin A droplets, increased
Web08. okt 2013. · Abstract and Figures. The human hepatic cell line LX-2 has been described as tool to study mechanisms of hepatic fibrogenesis and the testing of antifibrotic … http://www.diva-portal.org/smash/get/diva2:143297/FULLTEXT01.pdf
WebLoss of Lhx2 from developing hepatic stellate cells leads to their activation and excessive deposition of collagen fibres, resulting in hepatic fibrosis and severely distorted liver architecture. Transfection of Lhx2 to human stellate cell line downregulates genes associated with stellate cell activation and fibrogenesis. Thus, Lhx2 is the ... Web28. feb 2024. · Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) in the liver due to chronic injuries and inflammation. These injuries activate and transform quiescent hepatic stellate cells (HSCs) into proliferative myofibroblast-like cells, which are the key contributors to the secretin of ECM in the fibrotic liver. The insulin-like growth …
WebConclusion: Taken together, the cultured supernatant of normoxic exosome-educated HSCs enhances the lactate metabolism of hypoxic tumor cells via the IL-6/STAT3 pathway, in order to confer the SN38 resistance in a mimic liver metastatic microenvironment. Keywords: exosomes, hepatic stellate cells, lactate metabolism, colorectal liver metastasis.
Web05. okt 2024. · The dynamic shift in HSC subpopulations and their mediators during chronic liver disease is associated with a switch from HCC protection to HCC promotion. Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced … postitoimipaikatWeb10. dec 2004. · LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease by retaining key features of HSCs and having a retinoid phenotype typical of stellate cells. Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing … postitoimipaikkaWebActivation of hepatic stellate cells (HSC) is a key event in the initiation of liver fibrosis. Activated HSCs proliferate and secrete excessive amounts of extracellular matrix (ECM), … postitoimipaikka hakuWeb12. apr 2024. · Recently, several studies have shown that extracellular vesicles (EVs) derived from hepatic stellate cells (HSCs) could modulate liver fibrosis; however, there is a large gap in understanding whether inhibition of fibrogenic EVs derived from HSCs could alleviate the progression of liver fibrosis. Here, we investigated the role of FNDC5/irisin ... postitoimipaikat turkuWebThe LX-2 Cas9 human hepatic stellate cell line has been extensively characterized and retains key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making it a highly suitable model of human hepatic fibrosis. Key Applications. Cell Culture. Cell Function Assay. postitoimipaikka helsinkiWebStellate cells are neurons in the central nervous system, named for their star-like shape formed by dendritic processes radiating from the cell body. Many stellate cells are GABAergic and are located in the molecular layer of the cerebellum. Stellate cells are derived from dividing progenitor cells in the white matter of postnatal cerebellum. … postitoimipaikka englanniksiWebThis review article summarizes 20 years of our research on hepatic stellate cells within the framework of two collaborative research centers CRC575 and CRC974 at the Heinrich … postitoimipaikka ruotsiksi