Trichoplein

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August undefined, 2024

WebAug 25, 2024 · We have shown that trichoplein (TCHP), a centriolar protein originally identified as a keratin-binding protein, is a key activator of aurora A kinase (AURKA) at centrioles and that knockdown (KD) of TCHP causes elongation of primary cilia in human retinal pigmental epithelium cells by suppressing the inhibitory effect of AURKA in … WebDec 29, 2015 · Effects of trichoplein depletion on cell cycle regulators. Proliferating RPE1 cells were transfected with siRNA for control or trichoplein (#1 and #2), and then cultured for 72 h. The cell extracts were subjected to immunoblotting analysis with p27 Kip1, p53, p21 Cip1, p16 INK4a, trichoplein, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

(PDF) Ndel1 suppresses ciliogenesis in proliferating cells by ...

WebMar 1, 2005 · Keratins 8 and 18 (K8/18) are major components of the intermediate filaments (IFs) of simple epithelia. We report here the identification of a novel protein termed … WebDive into the research topics where David Mellis is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 1 Similar Profiles. P62 Chemical Compounds. 100%. anillin Medicine & Life Sciences. 85%. Endothelial Cells Medicine & Life Sciences. human good relias login

Depletion of Trichoplein (TpMs) Causes Chromosome Mis ... - MDPI

WebThe centrosomal protein trichoplein (TCHP) has been shown to promote cell cycle progression in the G 1-S phase by disassembling cilia. In this study, we showed that deletion of TCHP not only prevented the progression to the S phase but also resulted in cell cycle exit and entrance into G 0 phase. WebApr 26, 2024 · Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function.TCHP localizes to centriolar satellites, where it binds and stabilizes PCM 1. Loss of TCHP leads to delocalization and … WebMay 22, 2015 · Trichoplein negatively regulates ciliogenesis at mother centrioles, controls recruitment of microtubules to centrioles, and may play a role in maintenance of … holland ferguson attorney

Tchp Mouse Gene Details trichoplein, keratin filament binding ...

Tchp MGI Mouse Gene Detail - MGI:1925082 - trichoplein, keratin ...

WebMar 15, 2011 · Trichoplein – a widely expressed keratin intermediate filament scaffold protein – is shown by Masaki Inagaki and co-workers on page 857 to have a key role in … WebJan 19, 2024 · 1 Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.. 2 Research Center for Developmental Biology and Regenerative Medicine and. 3 Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.. 4 … human good redwood terraceWebNX_Q9BT92 - TCHP - Trichoplein keratin filament-binding protein - Function. Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell … humangood relias training

"WebApr 30, 2012 · Trichoplein or Aurora A knockdown failed to induce ciliogenesis or cell cycle arrest in HeLa cells, which, like many cancerous cell types, have a reduced tendency to form primary cilia. “We're now investigating whether Aurora A knockdown has different effects in various normal and cancer cell lines,” says Inagaki. " - Trichoplein

Trichoplein

WebApr 23, 2012 · Trichoplein disappears from the basal body in quiescent cells. (A) RPE1 cells were stained with antitrichoplein (Tricho.), anti-Odf2, and anti–Centrin 2. Bottom micrograph is shown with an illustration, which indicates the structure of a mother or daughter centriole (MC or DC) with the appendage (Ap) and orientations. Webケラチン結合蛋白質Trichopleinの中心体における機能解析(Trichoplein, a keratin binding protein, is a functional component of centrosomes) 大室有紀[松山], 鄒鵬, 猪子誠人, 衣斐美歩, 米村重信, 林裕子, 森大輔, 広常真治, 田村淳, 月田早智子, 稲垣昌樹

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WebApr 26, 2024 · Trichoplein (TCHP) is cytosolic ubiquitously expressed 62 kDa protein identified as a keratin filament binding protein 15. So far, the function of TCHP is deemed … WebAnti-trichoplein Antibody (G-2) is a mouse monoclonal IgG 1 κ trichoplein antibody, cited in 5 publications, provided at 200 µg/ml. raised against amino acids 94-201 mapping within an …

WebMar 21, 2024 · The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov … WebTrichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Authors - Andrea Martello. View Article. human: WB,IF: J Biol Chem. DAZ interacting protein 1 (Dzip1) phosphorylation by Polo-like kinase 1 (Plk1) regulates the centriolar satellites localization of the BBSome during the cell cycle.

WebHere, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites, where it binds and stabilizes PCM1. Loss of TCHP leads to delocalization and proteasome-dependent degradation of PCM1, further resulting in degradation of PCM1’s binding partner GABARAP. WebJun 1, 2001 · Trichoplein keratin filament-binding protein. Short names. Protein TCHP. Alternative names. Mitochondrial protein with oncostatic activity (Mitostatin) Tumor …

WebThus, the EGFR–USP8–trichoplein–AURKA axis suppresses ciliogenesis under serum cultivation, and serum deprivation downregulates the EGFR-USP8 pathway, which triggers trichoplein degradation and AURKA inactivation, resulting in ciliogenesis. These results were the first to reveal the mechanism of serum starvation–induced ciliogenesis.

Webtrichoplein (G-2): sc-515025 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com BACKGROUND Trichoplein, also known as THCP (trichoplein keratin filament-binding protein) or mitostatin (mitochondrial protein with oncostatic activity), is a 498 amino holland female womanWebJul 5, 2024 · Biomedicines 2024, 10, 1602 2 of 15 kinase Aurora A through a direct molecular interaction during centrioles activation at the G1‐phase, thus negatively regulating primary cilia assembly in this phase [5]. human good relias trainingWebWB analysis of MCF-7 using 25931-1-AP. MCF-7 cells were subjected to SDS PAGE followed by western blot with 25931-1-AP (TCHP Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25931-1-AP (TCHP Antibody) at dilution of 1:200 (under 40x lens). hollandfest cedar grove wiWebGeneral description. Trichoplein (TCHP) is also termed as mitostatin (TpMs). It is a keratin binding protein, which is partly located in the mitochondria. This gene is located on … holland festival 2023 long beachWebNdel1, a protein located at the subdistal appendage of mother centriole, functions as an upstream regulator of the trichoplein–Aurora A pathway that suppresses ciliogenesis in proliferating cells. (PDF) Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway Tohru Kiyono - Academia.edu holland festival cedar grove wiWebJun 14, 2024 · KCTD17 has also been reported to function as an adaptor of the cullin-3 ubiquitin ligase to mediate ubiquitination and degradation of trichoplein, which is a negative regulator of ciliogenesis. 32 Both neurons and astrocytes contain a primary cilium, and ciliogenesis has been reported to play an important role in brain development. 84 This ... holland festival cedar grove 2022WebBritish Heart Foundation - Search results humangood sun tower